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KMID : 0376319900020010173
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Dental Journal of CNU
1990 Volume.2 No. 1 p.173 ~ p.189
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EFFECTS OF MINOCYCLINE-HC1 AND DOXYCYCLINE HYCLATE ON EXTRACTED HUMAN ROOT SURFACE WITH PERIODONTAL DISEASE
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Kim Young-Joon
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Abstract
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This study was performed to investigate the effects of minocycline-HCI and doxycycline hyclate topically applied on extracted human root surface with periodontal disease using scanning electron microscope and bacterial growth inhibition test.
The results were as follows :
1. Scanning electron microscopic examination revealed no difference in concentration of 1㎎/㎖ minocycline-HCI and doxycycline hyclate solutions compaired with the root planed specimen without these solution conditioning.
In 10~25㎎/㎖ minocycline-HCI and doxycycline hyclate solutions, localized demineralization was observed in cementum. Above 50㎎/㎖, cemental collagen fibers in remained cemental surface and opened dentinal tubules in exposed dentinal surface were observed. This demineralizing effect was similar to the samples exposed to the citric acid.
2. In samples for evaluation of antimicrobial activity, all tooth slabs treated with minocycline-HCI and doxycycline hyclate solutions were found to inhibit bacterial growth, but no treated slabs were proven not to inhibit the bacterial growth.
This results suggest that the topical application of minocycline-HCI and doxycycline hyclate above 50㎎/㎖ in periodontal therapy may contribute to new attachment of connective tissue.
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